Anti-exercise Fatigue of Astragalus and Codonopsis Pilosula Extract and Expression of PGC-1  Protein

  • Xiaogang Xu
Keywords: Codonopsis pilosula extract; Anti-fatigue; Sports disclosure; PCG-1α


Objective: To study the anti-oxidation and anti-sports fatigue mechanism of Chinese herbal medicine Codonopsis pilosula extract. Methods: Randomly divide Kunming mice into blank control group, Codonopsis pilosula extract low dose group (100mg/(kg·d)), medium dose group (300mg/(kg·d)), high-dose group (600mg/(kg·d)), after feeding for 20 days, test the negative gravity swimming time, liver glycogen content, blood lactate, serum and urea nitrogen content after exercise And the expression of PGC-1α protein in the gastrocnemius muscle, and the oxidation resistance of the extracts of Astragalus and Codonopsis pilosula in different habitats were determined by spectrophotometry.Measurement results: Codonopsis pilosula extract significantly increased the exhaustion time of mice and significantly reduced blood lactic acid content (p<0.05); in addition, the serum urea nitrogen content in the high dose group decreased by 28.64% (p<0.01), hepatic glycogen The content increased by 30.30% (p<0.01). The results of Western Blod showed that the expression of PGC-1α in the high, middle and low dose groups was significantly higher than that in the blank group (p<0.05).Conclusion: It is suggested that the extract of Codonopsis pilosula is likely to reduce the accumulation of metabolites and increase the content of glycogen by increasing the expression of PGC-1α protein, thereby achieving anti-sport fatigue.