Pathogenesis of Alzheimer’s Disease and Statin Intervention

  • Ruirui Peng
Keywords: Alzheimer's disease; Endoplasmic reticulum stress; Apoptosis; Caspase-12; Atorvastatin


Statins are specific inhibitors of the cholesterol synthesis rate-limiting enzyme HMG% CoA reductase. It can
inhibit the activity of HMG% CoA, block mevalonate synthesis, reduce intracellular cholesterol content, and upregulate
low-density lipids in the liver. Protein (LDL) receptor gene expression. In this paper, AD rat models
were established by laterally injected AP25-35 into the lateral ventricle. Western-Blot and RT-PCR methods
were used to detect the expression of Caspase-12 protein in the brain tissue of rats in each experimental group.
Web Stress Mechanism. Atorvastatin can down-regulate the expression of caspase-12 protein in experimental
AD model rats, and significantly improve the learning and memory ability of experimental AD rats. Stress is
achieved, which may also be one of the mechanisms of action of atorvastatin against AD. Provide new
theoretical basis and ideas for clinical treatment of AD.