Effects of Continuous Activation of β-Catenin on Bone Mass and Bone Growth

  • Tang Shanbing
Keywords: Wnt / β-catenin pathway; Amino acid; Bone growth; FGF23 expression


This paper observes the effects of β-catenin activation in different periods on bone mass and bone growth in
mice, and explores its mechanism. Although early activation of β-catenin can increase bone mass, the
development of mice is affected, showing smaller body size, shorter bones and shorter vertebral bodies. HE
staining and Safranin O staining showed that the growth plate of mice became longer, especially the mast layer
cells increased significantly and apoptosis decreased. However, the bone growth was not significantly affected
after the late activation of β-catenin; the continuous activation of β-catenin in the early stage reduced the blood
phosphorus level of mice, no significant change in blood calcium level, and the up-regulation of FGF23, which
may be the reason for bone growth retardation in mice. In the later stage, the blood phosphorus level was
reduced, and there was no difference in blood calcium level and FGF23 expression. Increased bone formation
and decreased bone resorption cause an increase in bone mass. However, early activation can cause bone growth
to be hindered. The possible mechanism is that hypophosphatemia and FGF23 up-regulation hinder the growth
plate development.